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Wesley College Undergraduate Research Published


08.27.2013

Two Wesley College students collaborated and researched a project that was published in the American Journal of Health Sciences. Ghada Alabed (biology, 2010) and Melissa Earley (mathematics, 2013) completed an undergraduate research project under the direction of Wesley Professor of Chemistry, Dr. Malcolm J. D’Souza. Alabed built the in-house database while she was an undergraduate and Earley incorporated that data and built the online database this past year.

This project involved the tabulation and analyses of a variety of chemical, clinical, and basic pharmacokinetic data of chemotherapy drugs. The undergraduates first built a web-accessible relational database containing 85 FDA approved cancer drugs. They then showed that commercial computational tools could be employed to predict potential biological and biochemical interactions between the drugs chemical structure and the targets in patients.

This project was in collaboration with Dr. Natalia Roberts, Bioinformatics Scientist, Georgetown University Medical Center, DC, and Dr. Fady Gerges, Doctor of Surgical Pathology, Doctors Pathology, Dover, Delaware. This publication was made possible by the Delaware INBRE program, supported by a grant from the National Institute of General Medical Sciences - NIGMS (8 P20 GM103446-13) from the National Institutes of Health.
 
This fall, Alabed joined the Wesley College science department as supervisor of laboratory services. After graduation, Earley has secured a software developer position at Highmark Blue Cross Blue Shield in Wilmington, Delaware. The peer-reviewed article can be accessed at http://journals.cluteonline.com/index.php/AJHS/article/view/8010.